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Sastry's 10-year study of New Orleans Katrina evacuees shows demographic differences between returning and nonreturning

Stafford says less educated, smaller investors more likely to sell off stock and lock in losses during market downturn

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Deirdre Bloome wins ASA award for work on racial inequality and intergenerational transmission

Bob Willis awarded 2015 Jacob Mincer Award for Lifetime Contributions to the Field of Labor Economics

David Lam is new director of Institute for Social Research

Elizabeth Bruch wins Robert Merton Prize for paper in analytic sociology

Next Brown Bag

Monday, Oct 12
Joe Grengs, Policy & Planning for Social Equity in Transportation

Mercury Accumulation and Accelerated Progression of Carotid Atherosclerosis: A Population-based Prospective 4-year Follow-up Study in Men in Eastern Finland.

Publication Abstract

Salonen, J.T., K. Seppanen, T.A. Lakka, R. Salonen, and George A. Kaplan. 2000. "Mercury Accumulation and Accelerated Progression of Carotid Atherosclerosis: A Population-based Prospective 4-year Follow-up Study in Men in Eastern Finland." Atherosclerosis, 148(2): 265-273.

Basic research and our previous studies have suggested that mercury exposure enhances lipid peroxidation and the risk of myocardial infarction, but there are no studies concerning the association between mercury accumulation and atherosclerosis. We therefore investigated whether high hair mercury content is associated with accelerated progression of carotid atherosclerosis, determined by ultrasonographic assessment of common carotid intima-media thickness (IMT), in a prospective study among 1014 men aged 42–60 years. In a linear regression model adjusting for other atherosclerotic risk factors, high hair mercury content was one of the strongest predictors of the 4-year increase in the mean IMT (P=0.0007). On the average, for each g/g increase in hair mercury content, there was an increment of 8 m (7.3% of the mean) in the 4-year IMT increase. Men with hair mercury content of <0.49, 0.49–0.91, 0.92–1.49, 1.50–2.81 and >2.81 g/g (fifths) had an IMT increase of 0.105, 0.102, 0.113, 0.107 and 0.140 mm/4 years, respectively (P=0.041 for heterogeneity between groups). The IMT increase was 0.034 mm/4 years (31.9%) greater in the highest fifth than in the other fifths (P<0.05 for the difference). These findings suggest that mercury accumulation in the human body is associated with accelerated progression of carotid atherosclerosis.

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