Monday, Dec 9
Sharon Kardia: Genomics in the Health & Retirement Study
Johnell, K., J. Merlo, John W. Lynch, and G. Blennow. 2004. "Neighbourhood Social Participation and Women's Use of Anxiolytic-Hypnotic Drugs: a Multilevel Analysis." Journal of Epidemiology and Community Health, 58(1): 59-64.
Study objectives: To identify and quantify a hypothesised collective effect of the neighbourhood on individual use of anxiolytic- hypnotic drugs ( AHD). To analyse the general impact of neighbourhood social participation on use of AHD, adjusting for individual characteristics. Design: Cross sectional analysis performed by multilevel logistic regression with women at the first level and neighbourhoods at the second level. Setting: Malmo ( 250 000 inhabitants), Sweden. Participants: 15 456 women aged 45 to 73, residing in 95 neighbourhoods in Malmo, who took part in the Malmo diet and cancer study ( 1991 - 1996). Main results: The prevalence of AHD use was 5.5% in the study sample. Overall, 1.7% of the total individual differences in the propensity for using AHD were explained by the neighbourhood level. This percentage, however, differed between different individuals. Low level of social participation in the neighbourhood was associated with higher probability of AHD use ( OR = 3.10 ( 95% CI 1.51 to 6.41)), independently of individual age, low social participation, low educational level, and living alone. This association was reduced ( OR = 2.01 ( 95% CI 0.97 to 4.14)) after the additional accounting for individual disability pension, low self rated health, stress, and medication for somatic disorders. Conclusions: The neighbourhood level of social participation seems to affect individual use of AHD, possibly through individual characteristics. However, neighbourhood boundaries play a minor part in understanding individual AHD use in the city of Malmo.
PMCID: PMC1757021. (Pub Med Central)