Home > Publications . Search All . Browse All . Country . Browse PSC Pubs . PSC Report Series

PSC In The News

RSS Feed icon

Neidert says decreasing relevance of marriage reflected in growing percent of one-person households

House says resolving socioeconomic inequalities, not spending more on health care, will improve health in America

Kusunoki, Hall, and Barber find obese teen girls less likely to use birth control

Highlights

Bob Willis awarded 2015 Jacob Mincer Award for Lifetime Contributions to the Field of Labor Economics

David Lam is new director of Institute for Social Research

Elizabeth Bruch wins Robert Merton Prize for paper in analytic sociology

Elizabeth Bruch wins ASA award for paper in mathematical sociology

Next Brown Bag

PSC Brown Bags will be back fall 2015


Ferrets as a Transmission Model for Influenza: Sequence Changes in Ha1 of Type a (H3n2) Virus

Archived Abstract of Former PSC Researcher

Herlocher, M.L., S. Elias, R. Truscon, S. Harrison, D. Mindell, Carl P. Simon, and A.S. Monto. 2001. "Ferrets as a Transmission Model for Influenza: Sequence Changes in Ha1 of Type a (H3n2) Virus." Journal of Infectious Diseases, 184(5): 542-546.

Ferrets were used as an animal model to study whether controlled transmission of type A influenza is similar to human transmission when sequence changes in HA1 are used as the outcome. Ferrets were infected initially with A/Sydney/5/97 (H3N2) or A/LA/1/87 (H3N2) intranasally, and transmission chains were established by housing infected ferrets with noninfected ferrets with no influenza antibody titer against the infecting virus. Ferrets infected with A/Sydney were seronegative for A/Sydney and A/LA; ferrets infected with A/LA were seronegative for A/LA but had hemagglutination inhibition titers against A/Sydney. Titers of naturally transmitted influenza were higher than those after direct intranasal infection, but lymphocyte counts from nasal washes diminished with transmission. Ferrets infected with A/LA had 2 amino acid differences in HA1 after transmission through 5 ferret cohorts, but those infected with A/Sydney had none. The results show the value of the ferret model. A/LA resembled the transmission of influenza in humans when under antibody pressure.

Browse | Search : All Pubs | Next