Home > Publications . Search All . Browse All . Country . Browse PSC Pubs . PSC Report Series

PSC In The News

RSS Feed icon

Almirall says comparing SMART designs will increase treatment quality for children with autism

Thompson says America must "unchoose" policies that have led to mass incarceration

Alter says lack of access to administrative data is "big drag on research"


Susan Murphy to speak at U-M kickoff for data science initiative, Oct 6, Rackham

Andrew Goodman-Bacon, former trainee, wins 2015 Nevins Prize for best dissertation in economic history

Deirdre Bloome wins ASA award for work on racial inequality and intergenerational transmission

Bob Willis awarded 2015 Jacob Mincer Award for Lifetime Contributions to the Field of Labor Economics

Next Brown Bag

Monday, Oct 12 at noon, 6050 ISR
Joe Grengs: Policy & planning for transportation equity

Homocysteine as a risk factor for CVD mortality in men with other CVD risk factors: the Kuopio Ischaemic Heart Disease Risk Factor (KIHD) study

Publication Abstract

Virtanen, J.K., S. Voutilainen, G. Alfthan, M.J. Korhonen, T.H. Rissanen, J. Mursu, George A. Kaplan, and J.T. Salonen. 2005. "Homocysteine as a risk factor for CVD mortality in men with other CVD risk factors: the Kuopio Ischaemic Heart Disease Risk Factor (KIHD) study." Journal of Internal Medicine, 257(3): 255-262.

Objective. Based on case-control and prospective studies elevated blood total homocysteine (tHcy) has been suggested to be an independent risk factor for cardiovascular diseases (CVD). The purpose of the study was to explore the joint effect of increased serum tHcy concentration and other risk factors on the risk of CVD mortality in middle-aged men without a history of heart disease or stroke. Design. A prospective, population-based Kuopio Ischaemic Heart Disease Risk Factor (KIHD) Study.

Setting. Eastern Finland.

Subjects. A total of 802 men aged 46-64 years, examined in 1991-93.

Main outcome measures. CVD mortality event.

Results. The mean serum tHcy concentration was 10.8 mu mol L-1 (SD 3.3). During the average follow-up time of 10.8 years 50 men experienced a CVD death. The hazard rate ratio for CVD mortality was 1.80 (95% confidence interval: 1.02-3.19) in men in the highest serum tHcy third versus lower thirds after adjustment for cardiovascular risk factors. Furthermore, elevated serum tHcy concentration appeared to increase the risk of CVD death in men who smoke or who have high circulating concentrations of serum total or LDL cholesterol, apo-B apolipoprotein or plasma fibrinogen.

Conclusion. We conclude that homocysteine may increase the risk of CVD mortality in middle-aged men from Eastern Finland, and it may especially increase the risk when present with other risk factors for CVD.

DOI:10.1111/j.1365-2796.2005.01450.x (Full Text)

Country of focus: Finland.

Browse | Search : All Pubs | Next