Home > Publications . Search All . Browse All . Country . Browse PSC Pubs . PSC Report Series

PSC In The News

RSS Feed icon

Murphy on extending health support via a smart phone and JITAI

New analysis counters Shaefer's finding that households living on $2/day/person rose post welfare reform

Former trainee Herbert says residential squatters may be a good thing

More News

Highlights

Michigan ranked #12 on Business Insider's list of 50 best American colleges

Frey's new report explores how the changing US electorate could shape the next 5 presidential elections, 2016 to 2032

U-M's Data Science Initiative offers expanded consulting services via CSCAR

Elizabeth Bruch promoted to Associate Professor

Next Brown Bag

PSC Brown Bags
will resume fall 2016

Digoxin Therapy and the Risk of Primary Cardiac Arrest in Patients With Congestive Heart Failure - Effect of Mild-Moderate Renal Impairment

Publication Abstract

Rea, T. D , D.S. Siscovick, B.M. Psaty, R.M. Pearce, Trivellore Raghunathan, E.A. Whitsel, L.A. Cobb, S. Weinmann, G.D. Anderson, P. Arbogast, and D.Y. Lin. 2003. "Digoxin Therapy and the Risk of Primary Cardiac Arrest in Patients With Congestive Heart Failure - Effect of Mild-Moderate Renal Impairment." Journal of Clinical Epidemiology, 56:646-650.

Background and Objective: The cardiac safety of digoxin therapy for congestive heart failure (CHF) is a source of concern, especially among those with renal impairment. Methods: Using a case-control design, we examined the risk of primary cardiac arrest (PCA) associated with digoxin therapy within three levels of renal function. Results: After adjustment for other clinical characteristics, digoxin therapy for CHF was not associated with an increased risk of PCA [odds ratio (OR) = 0.97, 95% confidence interval (CI) 0.59-1.621 among patients with normal renal function (serum creatinine less than or equal to 1.1 mg/ dL). In contrast, digoxin therapy was associated with a modest increase in risk (OR 1.58, Cl 0.89-2.80) among patients with mild renal impairment (serum creatinine = 1.2-1.4 mg/dL); and a twofold increase in risk (OR 2.39, CI 1.37-4.18) among patients with moderate renal impairment (serum creatinine = 1.5-3.5 mg/dL). Conclusions: These findings suggest that the risks of digoxin may offset the benefits among patients with moderately impaired renal function, but not among patients with normal renal function. (C) 2003 Elsevier Inc. All rights reserved.

Browse | Search : All Pubs | Next