Friedlander, Y., D.S. Siscovick, P. Arbogast, B.M. Psaty, S. Weinman, R.N. Lemaitre, Trivellore Raghunathan, and L.A. Cobb. 2002. "Sudden Death and Myocardial Infarction in First Degree Relatives as Predictors of Primary Cardiac Arrest." Atherosclerosis, 162:211-216.
The hypothesis that family history (FH) of myocardial infarction (MI) and FH of sudden death (SD) are both independent risk factors for primary cardiac arrest (PCA) was examined in a case-control study. PCA cases were attended by paramedics (1988-1994) and community-based age and sex matched controls were identified. Subjects (125-74 years) were free of prior clinically-recognized heart disease and major co-morbidity. Interviewers obtained a detailed history of MI and SD in first-degree relatives from Spouses of 235 cases and 374 control subjects. A parental history of early-onset SD (age < 65) was associated with an increased risk of PCA (odds ratio (OR) = 2.69, 95%, CI = 1.35-5.36), after adjustment for parental history of MI and other risk factors. A parental history of late-onset SD was not associated with PCA risk (OR = 0.94, 95% CI = 0.55-1.62). Additionally, parental history of SD was related to early-onset PCA (OR = 1.89 95%, CI = 1.08-3.30) but not to late-onset PCA (OR = 0.89, 95% CI = 0.49-1.61). In contrast, parental MI (early/late) was related to PCA (early late), after adjustment for other risk factors and parental history of SD. Similar results were observed in first-degree relatives. Findings suggest a potential role of familial factors related to both MI and SD in PCA. Stronger findings for a familial patterning of PCA were noted for early onset disease in cases and their relatives. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.