Home > Publications . Search All . Browse All . Country . Browse PSC Pubs . PSC Report Series

PSC In The News

RSS Feed icon

H. Luke Shaefer and colleagues argue for a universal child allowance

Hindustan Times points out high value of H-1B visas for US innovation, welfare, and tech firm profits

Novak, Geronimus, Martinez-Cardoso: Threat of deportation harmful to immigrants' health

More News

Highlights

Heather Ann Thompson wins Pulitzer Prize for book on Attica uprising

Lam explores dimensions of the projected 4 billion increase in world population before 2100

ISR's Nick Prieur wins UMOR award for exceptional contribution to U-M's research mission

How effectively can these nations handle outside investments in health R&D?

More Highlights

Sioban D. Harlow photo

Evaluation of four proposed bleeding criteria for the onset of late menopausal transition

Publication Abstract

Harlow, Sioban D., K. Cain, S. Crawford, L. Dennerstein, R. Little, E.S. Mitchell, B. Nan, J.F. Randolph, J. Taffee, and M. Yosef. 2006. "Evaluation of four proposed bleeding criteria for the onset of late menopausal transition." Journal of Clinical Endocrinology and Metabolism, 91(9), 3432-3438.

Context: The current criterion for onset of late menopausal transition is amenorrhea of 90 d or more. The Stages of Reproductive Aging Workshop proposed alternative criteria based on a shorter period of amenorrhea. Empirical data comparing proposed criteria are not available.

Objective: This paper evaluates the several bleeding criteria that served as the basis of these recommendations. The goal was to provide empirically based guidance regarding which bleeding criterion may be optimal for widespread application in clinical and research settings.

Design/Setting: The study used prospective menstrual calendar data from four community and population-based cohort studies: TREMIN, Melbourne Women's Midlife Health Project, Seattle Midlife Women's Health Study, and Study of Women's Health Across the Nation.

Participants: The study included 735 TREMIN, 279 Seattle Midlife Women's Health Study, 216 Melbourne Women's Midlife Health Project, and 2270 Study of Women's Health Across the Nation women aged 35 - 57 yr at baseline who contributed 10 menstrual cycles or more.

Main Outcome Measure(s): The main measures were the frequency of and median age at occurrence and time from occurrence to final menstrual period (FMP) for four criteria: skipped segment, 10-segment running range, 60- and 90-d amenorrhea.

Results: A skipped segment, 10-segment running range greater than 42 d and 60- d amenorrhea identify a similar time in women's reproductive lives. The latter two identify the exact same date in two thirds of women. All three criteria occur in a greater proportion of women than the 90-d criterion and are equally predictive of the FMP, although they occur 1 - 2 yr earlier.

Conclusions: These findings support the recommendation of the Stages of Reproductive Aging Workshop that 60 d of amenorrhea be used to define onset of the late menopausal transition.

DOI:10.1210/jc.2005-2810 (Full Text)

PMCID: PMC1950694. (Pub Med Central)

Browse | Search : All Pubs | Next