Home > Publications . Search All . Browse All . Country . Browse PSC Pubs . PSC Report Series

PSC In The News

RSS Feed icon

Stafford says too early to say whether stock market declines will curtail Americans' spending

Eisenberg says many colleges now train campus personnel to spot and refer troubled college students

Farley on new strategies for city insolvencies in Michigan

Highlights

Call for papers: Conference on Integrating Genetics and the Social Sciences, Oct 21-22, 2016, CU-Boulder

PRB training program in policy communication for pre-docs. Application deadline, 2.28.2016

Call for proposals: PSID small grants for research on life course impacts on later life wellbeing

PSC News, fall 2015 now available

Next Brown Bag

Monday, Feb 1 at noon, 6050 ISR-Thompson
Sarah Miller

Low bone mineral density in the early menopausal transition: Role for ovulatory function

Publication Abstract

Grewal, Jagteshwar, MaryFran R. Sowers, John F. Randolph, Sioban D. Harlow, and Xihong Lin. 2006. "Low bone mineral density in the early menopausal transition: Role for ovulatory function." Journal of Clinical Endocrinology and Metabolism, 91(10): 3780-3785.

Objective and Context: The objective of the study was to determine whether luteal abnormalities or measures of sex steroid hormones collected across a menstrual cycle were associated with bone mineral density (BMD) at the total hip or lumbar spine.

Design and Setting: The Study of Women's Health Across the Nation is a longitudinal, community-based study conducted at seven clinical sites. Study of Women's Health Across the Nation includes a daily hormone study substudy in which daily urine samples are collected for one menstrual cycle ( up to a maximum of 50 d) each year.

Participants: Participants included 643 pre- and perimenopausal women, aged 43-53 yr.

Main Outcome Measures: BMD of the lumbar spine and total hip was measured by dual-energy x-ray densitometry. Daily urine samples were assayed for estrone conjugates, pregnanediol glucuronide, LH, and FSH, and the information from across the menstrual cycle was expressed as area under the curve (AUC). BMD levels were evaluated in relation to three menstrual cycle attributes: 1) absence or presence of ovulation; 2) luteal phase length to menstrual cycle length ratio; and 3) ovulatory disturbances, defined as anovulatory cycles or cycles with short luteal phases (< 10 d).

Results: Lower urine estrone conjugate AUC and higher urine FSH AUC were significantly associated with lower BMD. However, luteal abnormalities based on menstrual cycle attributes were not significantly associated with BMD at the total hip or lumbar spine after adjustment for age, body mass index, urinary hormone concentrations, menopausal status, and race/ethnicity.

Conclusions: Direct measures of urinary hormones, not menstrual cycle luteal abnormalities, were associated with lower levels of BMD.

DOI:10.1210/jc.2006-0544 (Full Text)

Browse | Search : All Pubs | Next