Mon, Feb 13, 2017, noon:
Daniel Almirall, "Getting SMART about adaptive interventions"
Katon, W., J. Unutzer, M.Y. Fan, J.W. Williamn, Michael Schoenbaum, E. H B Lin, and E.M. Hunkeler. 2006. "Cost-effectiveness and net benefit of enhanced treatment of depression for older adults with diabetes and depression." Diabetes Care, 29(2): 265-270.
OBJECTIVE - To determine the incremental cost-effectiveness and net benefit of a depression collaborative care program compared with usual care for patients with diabetes and depression. RESEARCH DESIGN AND METHODS - This article describes a preplanned subgroup analysis of patients with diabetes from the Improving Mood-Promoting Access to Collaborative (IMPACT) randomized controlled trial. The setting for the study included 18 primary care clinics from eight health care organizations in five states. A total of 418 of 1,801 patients randomized to the IMPACT intervention (n = 204) versus usual care (n = 214) had coexisting diabetes. A depression care manager offered education, behavioral activation, and a choice of problem-solving treatment or support of antidepressant management by the primary care physician. The main outcomes were incremental cost-effectiveness and net benefit of the program compared with usual care. RESULTS - Relative to usual care, intervention patients experienced 115 (95% CI 72 - 159) more depression-free days over 24 months. Total outpatient costs were $25 (95% CI - 1,638 to 1,689) higher during this same period. The incremental cost per depression-free day was 25 cents (-$14 to $15) and the incremental cost per quality-aqjusted life year ranged from $198 . (144-316) to $397 (287 - 641). An incremental net benefit of $1,129 (692 - 1,572) was found. CONCLUSIONS - The IMPACT intervention is a high-value investment for older adults with diabetes; it is associated with high clinical benefits at no greater cost than usual care.