Monday, Dec 9
Sharon Kardia: Genomics in the Health & Retirement Study
Lin, J.Y., T.R. Ten Have, H.R. Bogner, and Michael R. Elliott. 2007. "Baseline patient characteristics and mortality associated with longitudinal intervention compliance." Statistics in Medicine, 26(28): 5100-5115.
Lin et al. (http://www.biostatsresearch.com/upennbiostat/papers/, 2006) proposed a nested Markov compliance class model in the Imbens and Rubin compliance class model framework to account for time-varying subject noncompliance in longitudinal randomized intervention studies. We use superclasses, or latent compliance class principal strata, to describe longitudinal compliance patterns, and time-varying compliance classes are assumed to depend on the history of compliance. In this paper, we search for good subject-level baseline predictors of these superclasses and also examine the relationship between these superclasses and all-cause mortality. Since the superclasses are completely latent in all subjects, we utilize multiple imputation techniques to draw inferences. We apply this approach to a randomized intervention study for elderly primary care patients with depression.