Home > Publications . Search All . Browse All . Country . Browse PSC Pubs . PSC Report Series

PSC In The News

RSS Feed icon

Former trainee Herbert says residential squatters may be a good thing

Work by Couper, Farley et al. shows impact of racial composition on neighborhood choice

Thompson details killings and shaping of official narrative in 1971 Attica prison uprising

More News

Highlights

Michigan ranked #12 on Business Insider's list of 50 best American colleges

Frey's new report explores how the changing US electorate could shape the next 5 presidential elections, 2016 to 2032

U-M's Data Science Initiative offers expanded consulting services via CSCAR

Elizabeth Bruch promoted to Associate Professor

Next Brown Bag

PSC Brown Bags
will resume fall 2016

C-reactive protein mediates the effect of apolipoprotein E on cytomegalovirus infection

Archived Abstract of Former PSC Researcher

Aiello, A.E., H.O. Nguyen, and Mary Haan. 2008. "C-reactive protein mediates the effect of apolipoprotein E on cytomegalovirus infection." Journal of Infectious Diseases, 197:34-41.

Background. Although the apolipoprotein (APOE)-epsilon 4 allele has been shown to determine the outcome of several infections, its relationship with cytomegalovirus (CMV) has not been explored. We examine whether APOE determines CMV and herpes simplex virus type 1 (HSV-1) antibody levels and assess whether C-reactive protein (CRP) mediates any observed relationships. Methods. We conducted a cross-sectional analysis of a randomly selected subset (n = 1561/1789) of participants aged 60-101 in the Sacramento Area Latino Study on Aging. Blood samples were tested for APOE genotype, CRP, and immunoglobulin G antibodies to CMV and HSV-1. Multivariate logistic regression was used to examine the association between epsilon 4 and CMV and HSV antibody levels. We also assessed whether CRP mediates the effects of any observed associations between epsilon 4 and viral antibody levels. Results. CMVantibody and CRP levels varied significantly by APOE genotype. The association between CRP and CMV antibody was strengthened in the presence of epsilon 4. In contrast, this effect was not observed in HSV-1. We found that APOE-epsilon 4 carriers had significantly lower levels of CRP yet significantly higher levels of CMV antibodies, suggesting a mediating pathway. Conclusions. APOE-epsilon 4 carriers may experience immunological aberrations that lead to lower levels of CRP and correspondingly higher CMV antibody levels.

DOI:10.1086/524144 (Full Text)

Country of focus: United States of America.

Browse | Search : All Pubs | Next