Home > Publications . Search All . Browse All . Country . Browse PSC Pubs . PSC Report Series

PSC In The News

RSS Feed icon

Surprising findings on what influences unintended pregnancy from Wise, Geronimus and Smock

Recommendations on how to reduce discrimination resulting from ban-the-box policies cite Starr's work

Brian Jacob on NAEP scores: "Michigan is the only state in the country where proficiency rates have actually declined over time."

More News

Highlights

Call for papers: Conference on computational social science, April 2017, U-M

Sioban Harlow honored with 2017 Sarah Goddard Power Award for commitment to women's health

Post-doc fellowship in computational social science for summer or fall 2017, U-Penn

ICPSR Summer Program scholarships to support training in statistics, quantitative methods, research design, and data analysis

More Highlights

Next Brown Bag

Mon, March 13, 2017, noon:
Rachel Best

Cardiovascular fitness and exercise as determinants of insulin resistance in postpubertal adolescent females

Archived Abstract of Former PSC Researcher

Kasa-Vubu, J.Z., C.C. Lee, A. Rosenthal, K. Singer, and Jeffrey Halter. 2005. "Cardiovascular fitness and exercise as determinants of insulin resistance in postpubertal adolescent females." Journal of Clinical Endocrinology and Metabolism, 90(2): 849-854.

In obese adolescents, body mass index (BMI) is a poor predictor of insulin resistance, and the potential role of diminished physical activity has not been quantitated. We measured possible determinants of sensitivity to insulin in 53 adolescent females with a BMI between the 10th and the 95th percentile. We hypothesized that across weight and fitness spectra, relative fat mass, rather than BMI, and cardiovascular fitness would be predictors of insulin resistance. We measured body composition by total-body dual x-ray absorptiometry. Self-reported weekly frequency of aerobic exercise for 1 h (RDE) was recorded, and maximal oxygen Consumption (VO(2)max) was measured. Insulin sensitivity was estimated by homeostasis model assessment index (HOMA(IR)) derived from fasting glucose and insulin concentrations. BMI was not related to HOMA(IR) (P = 0.20), RDE showed a marginal relationship (P = 0.049), whereas percent body fat and VO(2)max were significantly related to HOMA(IR) (P = 0.01 and 0.0008, respectively). In a multiple regression model, VO(2)max Was a more critical determinant of insulin resistance than percent body fat (P = 0.03 vs. P = 0.67) or RDE (P = 0.01 VS. 0.51). For prevention strategies in youth, physical inactivity may represent a greater metabolic risk than obesity alone.

DOI:10.1210/jc.2004-0455 (Full Text)

Country of focus: United States of America.

Browse | Search : All Pubs | Next