Home > Publications . Search All . Browse All . Country . Browse PSC Pubs . PSC Report Series

PSC In The News

RSS Feed icon

Geronimus says black-white differences in mortality "help silence black voices in the electorate"

Do universities need more conservative thinkers?

Starr critical of risk assessment scores for sentencing

Highlights

Frey's new report explores how the changing US electorate could shape the next 5 presidential elections, 2016 to 2032

U-M's Data Science Initiative offers expanded consulting services via CSCAR

Elizabeth Bruch promoted to Associate Professor

Susan Murphy elected to the National Academy of Sciences

Next Brown Bag

PSC Brown Bags
will resume fall 2016

Anti-Mullerian hormone and inhibin B in the definition of ovarian aging and the menopause transition

Publication Abstract

Sowers, M.R., A.D. Eyvazzadeh, D. McConnell, M. Yosef, M.L. Jannausch, D.W. Zhang, Sioban D. Harlow, and J.F. Randolph. 2008. "Anti-Mullerian hormone and inhibin B in the definition of ovarian aging and the menopause transition." Journal of Clinical Endocrinology and Metabolism, 93(9): 3478-3483.

Context/Objective: The objective of the study was to determine whether anti-Mullerian hormone (AMH) and inhibin B are viable endocrine biomarkers for framing the menopause transition from initiation to the final menstrual period (FMP). Design: We assayed AMH, inhibin B, and FSH in 300 archival follicular phase specimens from 50 women with six consecutive annual visits commencing in 1993 when all women were in the pre-and perimenopausal menopause stages. Subsequently each woman had a documented FMP. The assay results were fitted as individual-woman profiles and then related to time to FMP and age at FMP as outcomes. Results: Based on annual values from six time points prior to the FMP, (log)AMH longitudinal profiles declined and were highly associated with a time point 5 yr prior to FMP [including both observed and values below detection (P < 0.0001 and P = 0.0001, respectively)]. Baseline AMH profiles were also associated with age at FMP(P = 0.035). Models of declining (log) inhibin B profiles (including both observed and values below detection) were associated with time to FMP(P < 0.0001 and P = 0.0003, respectively). There was no significant association of (log)inhibin B profiles with age at FMP. Conclusions: AMH, an endocrine marker that reflects the transition of resting primordial follicles to growing follicles, declined to a time point 5 yr prior to the FMP; this may represent a critical biological juncture in the menopausetransition. Low and nondetectable levels inhibin B levels also were observed 4-5 yr prior to the FMP but were less predictive of time to FMP or age at FMP.

DOI:10.1210/jc.2008-0567 (Full Text)

PMCID: PMC2567855. (Pub Med Central)

Licensed Access Link

Browse | Search : All Pubs | Next