Home > Publications . Search All . Browse All . Country . Browse PSC Pubs . PSC Report Series

PSC In The News

RSS Feed icon

Murphy says mobile sensor data will allow adaptive interventions for maximizing healthy outcomes

Frey comments on why sunbelt metro area economies are still struggling

Krause says having religious friends leads to gratitude, which is associated with better health

Highlights

PSC Fall 2014 Newsletter now available

Martha Bailey and Nicolas Duquette win Cole Prize for article on War on Poverty

Michigan's graduate sociology program tied for 4th with Stanford in USN&WR rankings

Jeff Morenoff makes Reuters' Highly Cited Researchers list for 2014

Next Brown Bag

Monday, Nov 3
Melvin Stephens

Susan A. Murphy photo

Screening Experiments for Developing Dynamic Treatment Regimes

Publication Abstract

Murphy, Susan A., and D. Bingham. 2009. "Screening Experiments for Developing Dynamic Treatment Regimes." Journal of the American Statistical Association, 104(485): 391-408.

Dynamic treatment regimes are time-varying treatments that individualize sequences of treatments to the patient. The construction of dynamic treatment regimes is challenging because a patient will be eligible for some treatment components only if he has not responded (or has responded) to other treatment components. In addition, there are usually a number of potentially useful treatment components and combinations thereof. In this article, we propose new methodology for identifying promising components and screening out negligible ones. First, we define causal factorial effects for treatment components that may be applied sequentially to a patient. Second, we propose experimental designs that can be used to study the treatment components. Surprisingly, modifications can be made to (fractional) factorial designs-more commonly found in the engineering statistics literature-for screening in this setting. Furthermore, we provide an analysis model that can be used to screen the factorial effects. We demonstrate the proposed methodology using examples motivated in the literature and also via a simulation study.

DOI:10.1198/jasa.2009.0119 (Full Text)

PMCID: PMC2892819. (Pub Med Central)

Country of focus: United States of America.

Browse | Search : All Pubs | Next