Home > Publications . Search All . Browse All . Country . Browse PSC Pubs . PSC Report Series

PSC In The News

RSS Feed icon

Frey's Scenario F simulation mentioned in account of the Democratic Party's tribulations

U-M Poverty Solutions funds nine projects

Dynarski says NY's Excelsior Scholarship Program could crowd out low-income and minority students

More News

Highlights

Workshops on EndNote, NIH reporting, and publication altmetrics, Jan 26 through Feb 7, ISR

2017 PAA Annual Meeting, April 27-29, Chicago

NIH funding opportunity: Etiology of Health Disparities and Health Advantages among Immigrant Populations (R01 and R21), open Jan 2017

Russell Sage 2017 Summer Institute in Computational Social Science, June 18-July 1. Application deadline Feb 17.

More Highlights

Next Brown Bag

Mon, Jan 23, 2017 at noon:
Decline of cash assistance and child well-being, Luke Shaefer

Endogenous red blood cell membrane fatty acids and sudden cardiac arrest

Publication Abstract

Lemaitre, R.N., I.B. King, N. Sotoodehnia, R.H. Knopp, D. Mozaffarian, B. McKnight, T.D. Rea, K. Rice, Y. Friedlander, T.S. Lumley, Trivellore Raghunathan, M.K. Copass, and D.S. Siscovick. 2010. "Endogenous red blood cell membrane fatty acids and sudden cardiac arrest." Metabolism: Clinical and Experimental, 59(7): 1029-1034.

Little is known of the associations of endogenous fatty acids with sudden cardiac arrest (SCA). We investigated the associations of SCA with red blood cell membrane fatty acids that are end products of de novo fatty acid synthesis: myristic acid (14:0), palmitic acid (16:0), palmitoleic acid (16:1 n7), vaccenic acid (18:1 n7), stearic acid (18:0), oleic acid (18:1 n9), and a related fatty acid, cis-7 hexadecenoic acid (16:1 n9). We used data from a population-based case-control study where cases, aged 25 to 74 years, were out-of-hospital SCA patients attended by paramedics in Seattle, WA (n = 265). Controls, matched to cases by age, sex, and calendar year, were randomly identified from the community (n = 415). All participants were free of prior clinically diagnosed heart disease. We observed associations of higher red blood cell membrane levels of 16:0, 16:1n-7, 18:1n-7, and 16:1n-9 with higher risk of SCA. In analyses adjusted for traditional SCA risk factors and trans- and n-3 fatty acids, a 1-SD-higher level of 16:0 was associated with 38% higher risk of SCA (odds ratio, 1.38; 95% confidence interval, 1.12-1.70) and a 1-SD-higher level of 16:1n-9 with 88% higher risk (odds ratio, 1.88; 95% confidence interval, 1.27-2.78). Several fatty acids that are end products of fatty acid synthesis are associated with SCA risk. Further work is needed to investigate if conditions that favor de novo fatty acid synthesis, such as high-carbohydrate/low-fat diets, might also increase the risk of SCA. (C) 2010 Elsevier Inc. All rights reserved.

DOI:10.1016/j.metabol.2009.10.026 (Full Text)

PMCID: PMC2882498. (Pub Med Central)

Country of focus: United States of America.

Browse | Search : All Pubs | Next