Home > Publications . Search All . Browse All . Country . Browse PSC Pubs . PSC Report Series

PSC In The News

RSS Feed icon

Thompson says America must "unchoose" policies that have led to mass incarceration

Axinn says new data on campus rape will "allow students to see for themselves the full extent of this problem"

Frey says white population is growing in Detroit and other large cities


Susan Murphy to speak at U-M kickoff for data science initiative, Oct 6, Rackham

Andrew Goodman-Bacon, former trainee, wins 2015 Nevins Prize for best dissertation in economic history

Deirdre Bloome wins ASA award for work on racial inequality and intergenerational transmission

Bob Willis awarded 2015 Jacob Mincer Award for Lifetime Contributions to the Field of Labor Economics

Next Brown Bag

Monday, Oct 5 at noon, 6050 ISR
Colter Mitchell: Biological consequences of poverty

Case Report: The University of Michigan Dioxin Exposure Study: A Follow-up Investigation of a Case with High Serum Concentration of 2,3,4,7,8-Pentachlorodibenzofuran

Publication Abstract

Franzblau, Alfred, Elizabeth Hedgeman, Olivier Jolliet, Kristine Knutson, Tim Towey, Qixuan Chen, Biling Hong, Avery Demond, David H. Garabrant, Brenda W. Gillespie, and James M. Lepkowski. 2010. "Case Report: The University of Michigan Dioxin Exposure Study: A Follow-up Investigation of a Case with High Serum Concentration of 2,3,4,7,8-Pentachlorodibenzofuran." Environmental Health Perspectives, 118(9): 1313-1317.

CONTEXT: Polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and dioxin-like polychlorinated biphenyls that have toxic equivalency factors (TEFs) were measured in serum of 946 subjects in five Michigan counties. The study was motivated by concerns about human exposure to dioxin-contaminated sediments in the Tittabawassee River (TR). Most of the toxic equivalency in TR sediments is from two furan congeners, 2,3,7,8-tetrachlorodibenzofuran and 2,3,4,7,8-pentachlorodibenzofuran (2,3,4,7,8-pentaCDF).

CASE PRESENTATION: The individual with the highest adjusted (for age, age squared, and body mass index) serum level of 2,3,4,7,8-pentaCDF in the study (42.5 ppt) reported a unique history of raising cattle and vegetables in the floodplain of the TR. Interviews and serum samples were obtained from the index case and 15 other people who ate beef and vegetables raised by the index case. 2,3,4,7,8-pentaCDF in beef lipid was estimated to have been more than three orders of magnitude greater than background (1,780 vs. 1.1 ppt). The mean, median, and 95th percentile for serum 2,3,4,7,8-pentaCDF in the study control population were 6.0, 5.4, and 13.0 ppt, respectively, and were 9.9, 8.4, and 20.5 ppt among beef and vegetable consumers, respectively. Back extrapolation for the index case suggests that his increase in serum concentration of 2,3,4,7,8-pentaCDF above background may have been as high as 146 ppt.

DISCUSSION: Consumption of beef and/or vegetables raised on dioxin-contaminated soil may be an important completed pathway of exposure.

RELEVANCE TO PUBLIC HEALTH PRACTICE: Animals and crops should not be raised for human consumption in areas contaminated with dioxins.

DOI:10.1289/ehp.0901723 (Full Text)

PMCID: PMC2944095. (Pub Med Central)

Country of focus: United States of America.

Browse | Search : All Pubs | Next