Home > Publications . Search All . Browse All . Country . Browse PSC Pubs . PSC Report Series

PSC In The News

RSS Feed icon

Thompson casts doubt on the rehabilitative intentions of prison labor

Inglehart says European social democracy is a victim of its own success

Bound, Khanna, and Morales find multiple effects of H1-B visas on US tech industry

More News

Highlights

Heather Ann Thompson wins Bancroft Prize for History for 'Blood in the Water'

Michigan ranks in USN&WR top-10 grad schools for sociology, public health, labor economics, social policy, social psychology

Paula Lantz to speak at Women in Health Leadership Summit, March 24, 2:30-5:30 Michigan League

New site highlights research, data, and publications of Relationship Dynamics and Social Life study

More Highlights

Next Brown Bag

Mon, March 20, 2017, noon:
Dean Yang, Taken by Storm

Case Report: The University of Michigan Dioxin Exposure Study: A Follow-up Investigation of a Case with High Serum Concentration of 2,3,4,7,8-Pentachlorodibenzofuran

Publication Abstract

Franzblau, Alfred, Elizabeth Hedgeman, Olivier Jolliet, Kristine Knutson, Tim Towey, Qixuan Chen, Biling Hong, Avery Demond, David H. Garabrant, Brenda W. Gillespie, and James M. Lepkowski. 2010. "Case Report: The University of Michigan Dioxin Exposure Study: A Follow-up Investigation of a Case with High Serum Concentration of 2,3,4,7,8-Pentachlorodibenzofuran." Environmental Health Perspectives, 118(9): 1313-1317.

CONTEXT: Polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and dioxin-like polychlorinated biphenyls that have toxic equivalency factors (TEFs) were measured in serum of 946 subjects in five Michigan counties. The study was motivated by concerns about human exposure to dioxin-contaminated sediments in the Tittabawassee River (TR). Most of the toxic equivalency in TR sediments is from two furan congeners, 2,3,7,8-tetrachlorodibenzofuran and 2,3,4,7,8-pentachlorodibenzofuran (2,3,4,7,8-pentaCDF).

CASE PRESENTATION: The individual with the highest adjusted (for age, age squared, and body mass index) serum level of 2,3,4,7,8-pentaCDF in the study (42.5 ppt) reported a unique history of raising cattle and vegetables in the floodplain of the TR. Interviews and serum samples were obtained from the index case and 15 other people who ate beef and vegetables raised by the index case. 2,3,4,7,8-pentaCDF in beef lipid was estimated to have been more than three orders of magnitude greater than background (1,780 vs. 1.1 ppt). The mean, median, and 95th percentile for serum 2,3,4,7,8-pentaCDF in the study control population were 6.0, 5.4, and 13.0 ppt, respectively, and were 9.9, 8.4, and 20.5 ppt among beef and vegetable consumers, respectively. Back extrapolation for the index case suggests that his increase in serum concentration of 2,3,4,7,8-pentaCDF above background may have been as high as 146 ppt.

DISCUSSION: Consumption of beef and/or vegetables raised on dioxin-contaminated soil may be an important completed pathway of exposure.

RELEVANCE TO PUBLIC HEALTH PRACTICE: Animals and crops should not be raised for human consumption in areas contaminated with dioxins.

DOI:10.1289/ehp.0901723 (Full Text)

PMCID: PMC2944095. (Pub Med Central)

Country of focus: United States of America.

Browse | Search : All Pubs | Next