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Miech on 'generational forgetting' about drug-use dangers

Impacts of H-1B visas: Lower prices and higher production - or lower wages and higher profits?

MTF data show 10% of 19-20 year-olds report bouts of drinking 10-plus alcoholic beverages

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Call for papers: Conference on computational social science, April 2017, U-M

Sioban Harlow honored with 2017 Sarah Goddard Power Award for commitment to women's health

Post-doc fellowship in computational social science for summer or fall 2017, U-Penn

ICPSR Summer Program scholarships to support training in statistics, quantitative methods, research design, and data analysis

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Next Brown Bag

Mon, Feb 13, 2017, noon:
Daniel Almirall, "Getting SMART about adaptive interventions"

Reinforcing and discriminative-stimulus effects of ephedrine isomers in rhesus monkeys

Archived Abstract of Former PSC Researcher

Anderson, Kermyt G., G. Winger, J. Woods, and W.L. Woolverton. 2001. "Reinforcing and discriminative-stimulus effects of ephedrine isomers in rhesus monkeys." Drug and Alcohol Dependence, 65(1): 45-53.

Ephedrine is a sympathomimetic drug that is currently found in many over-the-counter preparations. This compound exists as four isomers which. in addition to a racemic mixture, were evaluated for their positive reinforcing effects and for their similarity to (+)-amphetamine as a discriminative stimulus. Rhesus monkeys (N=3) with intravenous cocaine (0.1 mg/kg/inj) or saline as a consequence for lever pressing were shown to self-administer all of the ephedrine compounds (range tested: 0.03-3.0 mg/kg/inj), with the exception of (-)-pseudoephedrine, when each drug/dose was substituted for cocaine or saline during test sessions. However, the (-)-pseudoephedrine isomer was evaluated within a limited dose range due to solubility limitations. Systematically increasing the number of responses required for an injection indicated that these isomers were not as effective as reinforcers as was cocaine. Rhesus monkeys (N=3) trained to discriminate intragastric 1.0 mg/kg (+)-amphetamine from saline were given substitution tests with the ephedrine isomers and the racemic mixture. When given intragastrically, at least one dose of all the ephedrine isomers substituted for the (+)-amphetamine discriminative stimulus in at least one of the subjects tested. However, (+)-amphetamine-like effects were not systematically related to dose, When the discriminative-stimulus effects of (-)-ephedrine were also compared with those of (+)-amphetamine across three different routes of administration, full, dose-related, (+)-amphetamine-like responding was observed with both the intramuscular and intravenous routes. Taken together, these results suggest that the ephedrines have psychomotor stimulant-like abuse potential, lower than that of cocaine. Parenteral administration may enhance psychomotor-stimulant-like effects. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

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