Home > Publications . Search All . Browse All . Country . Browse PSC Pubs . PSC Report Series

PSC In The News

RSS Feed icon

Edin and Shaefer's book a call to action for Americans to deal with poverty

Weir says pain may underlie rise in suicide and substance-related deaths among white middle-aged Americans

Weitzman says China's one-child policy has had devastating effects on first-born daughters


MCubed opens for new round of seed funding, November 4-18

PSC News, fall 2015 now available

Barbara Anderson appointed chair of Census Scientific Advisory Committee

John Knodel honored by Thailand's Chulalongkorn University

Next Brown Bag

Monday, Dec 7 at noon, 6050 ISR-Thompson
Daniel Eisenberg, "Healthy Minds Network: Mental Health among College-Age Populations"

Evaluating the buffering vs. direct effects hypotheses of emotional social support on inflammatory markers: The Multi-Ethnic Study of Atherosclerosis

Archived Abstract of Former PSC Researcher

Mezuk, B., Ana Diez Roux, and T. Seeman. 2010. "Evaluating the buffering vs. direct effects hypotheses of emotional social support on inflammatory markers: The Multi-Ethnic Study of Atherosclerosis." Brain Behavior and Immunity, 24(8): 1294-1300.

Social support is associated with cardiovascular disease mortality, however, the physiologic mechanisms underlying this relationship remains unspecified This study evaluated the association of social support with inflammatory markers associated with cardiovascular risk C-reactive protein (CRP), interleukin-6 (IL-6), and fibrinogen We evaluated two competing models of the support-inflammation relationship first, that low social support is directly associated with inflammation, and second, that high support acts to buffer the effect of stress on inflammation Using data from the baseline interview of the Multi-Ethnic Study of Atherosclerosis (N = 6814, 53% female, age 45-84 years) we assessed the Independent and interacting associations of social support and stress with inflammation Social support was measured by the emotional social support index Stressors in multiple domains (work, family, finances, interpersonal) were assessed. Serum CRP, IL-6, and fibrinogen were analyzed from fasting samples using high-sensitivity assays Multivariate linear regression, including models stratified by gender and age group (45-64 and 65-84 years), was used to assess the direct and buffering relationships between social support, stress, and inflammation In bivariate analyses low social support was associated with higher levels of all three markers In adjusted models, low support was associated with higher InCRP (B 0 15, 95% Cl: 001, 0 30) among men but not women High social support buffered the relationship between stress and CRP among middle-aged women only (P for interaction 0 042) Overall, social support was only modestly associated with inflammation in this relatively healthy sample, and these relationships varied by age and gender (C) 2010 Elsevier Inc All rights reserved

DOI:10.1016/j.bbi.2010.06.006 (Full Text)

PMCID: PMC2949452. (Pub Med Central)

Country of focus: United States of America.

Browse | Search : All Pubs | Next