Home > Publications . Search All . Browse All . Country . Browse PSC Pubs . PSC Report Series

PSC In The News

RSS Feed icon

Yang comments on importance of migrant remittances to future of recipient families

Frey says America's black population is changing with recent immigration

Bailey and Danziger's War on Poverty book reviewed in NY Review of Books

Highlights

Cheng wins ASA Outstanding Graduate Student Paper Award

Hicken wins 2015 UROP Outstanding Research Mentor Award

U-M ranked #1 in Sociology of Population by USN&WR's "Best Graduate Schools"

PAA 2015 Annual Meeting: Preliminary program and list of UM participants

Next Brown Bag

Mon, May 18
Lois Verbrugge, Disability Experience & Measurement

"I know what you told me, but this is what I think;" perceived risk of Alzheimer disease among individuals who accurately recall their genetics-based risk estimate

Archived Abstract of Former PSC Researcher

Linnenbringer, Erin. 2010. ""I know what you told me, but this is what I think;" perceived risk of Alzheimer disease among individuals who accurately recall their genetics-based risk estimate." Genetics in Medicine, 12(4): 219-27.

Purpose: This study evaluates the Alzheimer disease risk perceptions of individuals who accurately recall their genetics-based Alzheimer disease risk assessment.

Methods: Two hundred forty-six unaffected first-degree relatives of patients with Alzheimer disease were enrolled in a multisite randomized controlled trial examining the effects of communicating APOE genotype and lifetime Alzheimer disease risk information.

Results: Among the 158 participants who accurately recalled their Alzheimer disease risk assessment 6 weeks after risk disclosure, 75 (47.5%) believed their Alzheimer disease risk was more than 5% points different from the Alzheimer disease risk estimate they were given. Within this subgroup, 69.3% believed that their Alzheimer disease risk was higher than what they were told (discordant high), whereas 30.7% believed that their Alzheimer disease risk was lower (discordant low). Participants with a higher baseline risk perception were more likely to have a discordant-high risk perception (P < 0.05). Participants in the discordant-low group were more likely to be APOE ε4 positive (P < 0.05) and to score higher on an Alzheimer disease controllability scale (P < 0.05).

Conclusion: Our results indicate that even among individuals who accurately recall their Alzheimer disease risk assessment, many people do not take communicated risk estimates at face value. Further exploration of this clinically relevant response to risk information is warranted.

PMCID: PMC2921681. (Pub Med Central)

Country of focus: United States of America.

Browse | Search : All Pubs | Next