Home > Publications . Search All . Browse All . Country . Browse PSC Pubs . PSC Report Series

PSC In The News

RSS Feed icon

Smock cited in story on how low marriage rates may exacerbate marriage-status economic inequality

Shapiro says Americans' seemingly volatile spending pattern linked to 'sensible cash management'

Work of Cigolle, Ofstedal et al. cited in Forbes story on frailty risk among the elderly

Highlights

Sarah Burgard and former PSC trainee Jennifer Ailshire win ASA award for paper

James Jackson to be appointed to NSF's National Science Board

ISR's program in Society, Population, and Environment (SPE) focuses on social change and social issues worldwide.

McEniry and Schoeni host Conference on Long-run Impacts of Early Life Events

Next Brown Bag


PSC Brown Bags will return in the fall

A “SMART” Design for Building Individualized Treatment Sequences

Publication Abstract

Lei, H., I. Nahum-Shani, K. Lynch, D. Oslin, and Susan A. Murphy. 2012. "A “SMART” Design for Building Individualized Treatment Sequences." Annual Review of Clinical Psychology, 8: 21-48.

Interventions often involve a sequence of decisions. For example, clinicians frequently adapt the intervention to an individual's outcomes. Altering the intensity and type of intervention over time is crucial for many reasons, such as to obtain improvement if the individual is not responding or to reduce costs and burden when intensive treatment is no longer necessary. Adaptive interventions utilize individual variables (severity, preferences) to adapt the intervention and then dynamically utilize individual outcomes (response to treatment, adherence) to readapt the intervention. The Sequential Multiple Assignment Randomized Trial (SMART) provides high-quality data that can be used to construct adaptive interventions. We review the SMART and highlight its advantages in constructing and revising adaptive interventions as compared to alternative experimental designs. Selected examples of SMART studies are described and compared. A data analysis method is provided and illustrated using data from the Extending Treatment Effectiveness of Naltrexone SMART study.

DOI:10.1146/annurev-clinpsy-032511-143152 (Full Text)

Browse | Search : All Pubs | Next