Home > Publications . Search All . Browse All . Country . Browse PSC Pubs . PSC Report Series

PSC In The News

RSS Feed icon

Shapiro says Twitter-based employment index provides real-time accuracy

Xie says internet censorship in China often reflects local officials' concerns

Cheng finds marriage may not be best career option for women

Highlights

Jeff Morenoff makes Reuters' Highly Cited Researchers list for 2014

Susan Murphy named Distinguished University Professor

Sarah Burgard and former PSC trainee Jennifer Ailshire win ASA award for paper

James Jackson to be appointed to NSF's National Science Board

Next Brown Bag


PSC Brown Bags will return in the fall

Social disorder, APOE-E4 genotype, and change in cognitive function among older adults living in Chicago

Archived Abstract of Former PSC Researcher

Boardman, J., L. Barnes, R. Wilson, D. Evans, and Carlos Mendes de Leon. 2012. "Social disorder, APOE-E4 genotype, and change in cognitive function among older adults living in Chicago." Social Science and Medicine, 74(10): 1584-1590.

The goal of this paper is to describe the simultaneous influence of social and genetic risk factors on declines in cognitive functioning among older American adults. We use detailed information about the social characteristics of older adults' neighborhoods from the Chicago Health and Aging Project (n = 1655: ages 65+) in conjunction with information about respondent's APOE genotype to predict changes in cognitive function over time. Results indicate that the presence of the epsilon 4 allele is associated with a significantly lower cognitive function score at baseline and greater declines in cognitive function compared to those without this risk allele. Importantly, we also show significant variation in the effect of the 4 allele across neighborhoods and our results indicate that this genotype is more strongly associated with cognitive function for residents of neighborhoods with the lowest levels of social disorder. Our findings support the non-causal social push gene environment interaction model. (C) 2012 Elsevier Ltd. All rights reserved.

DOI:10.1016/j.socscimed.2012.02.012 (Full Text)

PMCID: PMC3597347. (Pub Med Central)

Browse | Search : All Pubs | Next