Home > Publications . Search All . Browse All . Country . Browse PSC Pubs . PSC Report Series

PSC In The News

RSS Feed icon

Smock cited in story on how low marriage rates may exacerbate marriage-status economic inequality

Shapiro says Americans' seemingly volatile spending pattern linked to 'sensible cash management'

Work of Cigolle, Ofstedal et al. cited in Forbes story on frailty risk among the elderly

Highlights

Sarah Burgard and former PSC trainee Jennifer Ailshire win ASA award for paper

James Jackson to be appointed to NSF's National Science Board

ISR's program in Society, Population, and Environment (SPE) focuses on social change and social issues worldwide.

McEniry and Schoeni host Conference on Long-run Impacts of Early Life Events

Next Brown Bag


PSC Brown Bags will return in the fall

Edward Norton photo

Rank reversal in indirect comparisons

Publication Abstract

Norton, Edward, M. Miller, J. Wang, K. Coyne, and L. Kleinman. 2012. "Rank reversal in indirect comparisons." Value in Health, 15(8): 1137-40.

OBJECTIVE: To describe rank reversal as a source of inconsistent interpretation intrinsic to indirect comparison (Bucher HC, Guyatt GH, Griffith LE, Walter SD. The results of direct and indirect treatment comparisons in meta-analysis of randomized controlled trials. J Clin Epi 1997;50:683-91) of treatments and to propose best practice. METHODS: We prove our main points with intuition, examples, graphs, and mathematical proofs. We also provide software and discuss implications for research and policy. RESULTS: When comparing treatments by indirect means and sorting them by effect size, three common measures of comparison (risk ratio, risk difference, and odds ratio) may lead to vastly different rankings. CONCLUSIONS: The choice of risk measure matters when making indirect comparisons of treatments. The choice should depend primarily on the study design and the conceptual framework for that study.

DOI:10.1016/j.jval.2012.06.001 (Full Text)

PMCID: PMC3527821. (Pub Med Central)

Browse | Search : All Pubs | Next