Home > Publications . Search All . Browse All . Country . Browse PSC Pubs . PSC Report Series

PSC In The News

RSS Feed icon

Bailey and Dynarski's work cited in Bloomberg article on growing U.S. inequality

Frey says current minority college completion rates predict decline in college-educated Americans

Kimball and unnamed coauthor examine male bias in economics

Highlights

Call for Proposals: Small Grants for Research Using PSID Data. Due March 2, 2015

PSC Fall 2014 Newsletter now available

Martha Bailey and Nicolas Duquette win Cole Prize for article on War on Poverty

Michigan's graduate sociology program tied for 4th with Stanford in USN&WR rankings

Next Brown Bag

Monday, Jan 26
Jeff Smith, Consequences of Student-College Mismatch

Efficacy of fat-soluble vitamin supplementation in infants with biliary atresia

Publication Abstract

Shneider, B., J. Magee, J. Bezerra, B. Haber, S. Karpen, Trivellore Raghunathan, P. Rosenthal, K. Schwarz, F. Suchy, N. Kerkar, Y. Turmelle, P. Whitington, P. Robuck, R. Sokol, and N. Childhood Liver Disease Research Education. 2012. "Efficacy of fat-soluble vitamin supplementation in infants with biliary atresia." Pediatrics, 130(3): e607-14.

OBJECTIVE: Cholestasis predisposes to fat-soluble vitamin (FSV) deficiencies. A liquid multiple FSV preparation made with tocopheryl polyethylene glycol-1000 succinate (TPGS) is frequently used in infants with biliary atresia (BA) because of ease of administration and presumed efficacy. In this prospective multicenter study, we assessed the prevalence of FSV deficiency in infants with BA who received this FSV/TPGS preparation. METHODS: Infants received FSV/TPGS coadministered with additional vitamin K as routine clinical care in a randomized double-blinded, placebo-controlled trial of corticosteroid therapy after hepatoportoenterostomy (HPE) for BA (identifier NCT 00294684). Levels of FSV, retinol binding protein, total serum lipids, and total bilirubin (TB) were measured 1, 3, and 6 months after HPE. RESULTS: Ninety-two infants with BA were enrolled in this study. Biochemical evidence of FSV insufficiency was common at all time points for vitamin A (29%-36% of patients), vitamin D (21%-37%), vitamin K (10%-22%), and vitamin E (16%-18%). Vitamin levels were inversely correlated with serum TB levels. Biochemical FSV insufficiency was much more common (15%-100% for the different vitamins) in infants whose TB was >/=2 mg/dL. At 3 and 6 months post HPE, only 3 of 24 and 0 of 23 infants, respectively, with TB >2 mg/dL were sufficient in all FSV. CONCLUSIONS: Biochemical FSV insufficiency is commonly observed in infants with BA and persistent cholestasis despite administration of a TPGS containing liquid multiple FSV preparation. Individual vitamin supplementation and careful monitoring are warranted in infants with BA, especially those with TB >2 mg/dL.

DOI:10.1542/peds.2011-1423 (Full Text)

PMCID: PMC3428752. (Pub Med Central)

Browse | Search : All Pubs | Next