Home > Publications . Search All . Browse All . Country . Browse PSC Pubs . PSC Report Series

PSC In The News

RSS Feed icon

Yang comments on importance of migrant remittances to future of recipient families

Frey says America's black population is changing with recent immigration

Bailey and Danziger's War on Poverty book reviewed in NY Review of Books

Highlights

Hicken wins 2015 UROP Outstanding Research Mentor Award

U-M ranked #1 in Sociology of Population by USN&WR's "Best Graduate Schools"

PAA 2015 Annual Meeting: Preliminary program and list of UM participants

ISR addition wins LEED Gold Certification

Next Brown Bag

Mon, May 18
Lois Verbrugge, Disability Experience & Measurement

Longer Lived Parents: Protective Associations With Cancer Incidence and Overall Mortality

Archived Abstract of Former PSC Researcher

Dutta, Ambarish, William Henley, Jean-Marie Robine, Kenneth M. Langa, Robert Wallace, and David Melzer. 2013. "Longer Lived Parents: Protective Associations With Cancer Incidence and Overall Mortality." Journals of Gerontology Series A-Biological Sciences and Medical Sciences, 68(11): 1409-1418.

Background. Children of centenarians have lower cardiovascular disease prevalence and live longer. We aimed to estimate associations between the full range of parental attained ages and health status in a middle-aged U.S. representative sample.

Methods. Using Health and Retirement Study data, models estimated disease incidence and mortality hazards for respondents aged 51–61 years at baseline, followed up for 18 years. Full adjustment included sex, race, smoking, wealth, education, body mass index, and childhood socioeconomic status. Mother's and father's attained age distributions were used to define short-, intermediate-, and long-lived groups, yielding a ranked parental longevity score (n = 6,055, excluding short–long discordance). Linear models (n = 8,340) tested mother's or father's attained ages, adjusted for each other.

Results. With increasing mother's or father's survival (>65 years), all-cause mortality declined 19% (hazard ratio [HR] = 0.81, 95% CI: 0.76–0.86, p < .001) and 14% per decade (HR = 0.87, 95% CI: 0.81–0.92, p < .001). Estimates changed only modestly when fully adjusted. Parent-in-law survival was not associated with mortality (n = 1,809, HR = 1.00, 95% CI: 0.90–1.12, p = .98). Offspring with one or two long-lived parents had lower cancer incidence (938 cases, HR per parental longevity score = 0.76, 95% CI: 0.61–0.94, p = .01) versus two intermediate parents. Similar HRs for diabetes (HR = 0.89, 95% CI: 0.84–0.96, p = .001), heart disease (HR = 0.88, 95% CI: 0.82–0.93, p < .001), and stroke (HR = 0.86, 95% CI: 0.78–0.95, p = .002) were significant, but there was no trend for arthritis.

Conclusions. The results provide the first robust evidence that increasing parental attained age is associated with lower cancer incidence in offspring. Health advantages of having centenarian parents extend to a wider range of parental longevity and may provide a quantitative trait of slower aging.

DOI:10.1093/gerona/glt061 (Full Text)

PMCID: PMC3919622. (Pub Med Central)

Country of focus: United States of America.

Browse | Search : All Pubs | Next