Home > Publications . Search All . Browse All . Country . Browse PSC Pubs . PSC Report Series

PSC In The News

RSS Feed icon

Thompson says America must "unchoose" policies that have led to mass incarceration

Axinn says new data on campus rape will "allow students to see for themselves the full extent of this problem"

Frey says white population is growing in Detroit and other large cities


Susan Murphy to speak at U-M kickoff for data science initiative, Oct 6, Rackham

Andrew Goodman-Bacon, former trainee, wins 2015 Nevins Prize for best dissertation in economic history

Deirdre Bloome wins ASA award for work on racial inequality and intergenerational transmission

Bob Willis awarded 2015 Jacob Mincer Award for Lifetime Contributions to the Field of Labor Economics

Next Brown Bag

Monday, Oct 12 at noon, 6050 ISR
Joe Grengs: Policy & planning for transportation equity

Vascular health, diabetes, APOE and dementia: the Aging, Demographics, and Memory Study

Archived Abstract of Former PSC Researcher

Llewellyn, David J., Iain A. Lang, Fiona E. Matthews, Brenda L. Plassman, Mary A. M. Rogers, Lewis B. Morgenstern, Gwenith Fisher, Mohammed U. Kabeto, and Kenneth M. Langa. 2010. "Vascular health, diabetes, APOE and dementia: the Aging, Demographics, and Memory Study." Alzheimers Research & Therapy, 2(3): 19.

Introduction: Evidence from clinical samples and geographically limited population studies suggests that vascular health, diabetes and apolipoprotein epsilon 4 (APOE) are associated with dementia.

Methods: A population-based sample of 856 individuals aged 71 years or older from all contiguous regions of the United States received an extensive in-home clinical and neuropsychological assessment in 2001-2003. The relation of hypertension, diabetes, heart disease, stroke, medication usage, and APOE epsilon 4 to dementia was modelled using adjusted multivariable logistic regression.

Results: Treated stroke (odds ratio [OR] 3.8, 95% confidence interval [CI] 2.0, 7.2), untreated stroke (OR 3.5, 95% CI 1.7, 7.3), and APOE epsilon 4 (OR 2.8, 95% CI 1.7, 4.5) all increased the odds of dementia. Treated hypertension was associated with lower odds of dementia (OR 0.5, 95% CI 0.3, 1.0). Diabetes and heart disease were not significantly associated with dementia. A significant interaction was observed between APOE epsilon 4 and stroke (P = 0.001).

Conclusions: Data from the first dementia study that is representative of the United States population suggest that stroke, the APOE epsilon 4 allele and their interaction are strongly associated with dementia.

DOI:10.1186/alzrt43 (Full Text)

PMCID: PMC2919699. (Pub Med Central)

Browse | Search : All Pubs | Next