Home > Publications . Search All . Browse All . Country . Browse PSC Pubs . PSC Report Series

PSC In The News

RSS Feed icon

Groves keynote speaker at MIDAS symposium, Nov 15-16: "Big Data: Advancing Science, Changing the World"

Shaefer says drop child tax credit in favor of universal, direct investment in American children

Buchmueller breaks down partisan views on Obamacare

More News


Gonzalez, Alter, and Dinov win NSF "Big Data Spokes" award for neuroscience network

Post-doc Melanie Wasserman wins dissertation award from Upjohn Institute

ISR kicks off DE&I initiative with lunchtime presentation: Oct 13, noon, 1430 ISR Thompson

U-M ranked #4 in USN&WR's top public universities

More Highlights

Next Brown Bag

Mon, Oct 24 at noon:
Academic innovation & the global public research university, James Hilton

Colter Mitchell photo

Social disadvantage, genetic sensitivity, and children’s telomere length

Publication Abstract

Mitchell, Colter, John Hobcraft, Sara McLanahan, Susan Rutherford Siegel, Arthur Berg, Jeanne Brooks-Gunn, Irwin Garfinkel, and Daniel Notterman. 2014. "Social disadvantage, genetic sensitivity, and children’s telomere length." Proceedings of the National Academy of Sciences of the United States of America, 111(16): 5944-5949.

Disadvantaged social environments are associated with adverse health outcomes. This has been attributed, in part, to chronic stress. Telomere length (TL) has been used as a biomarker of chronic stress: TL is shorter in adults in a variety of contexts, including disadvantaged social standing and depression. Using data from 40, 9-year-old boys participating in the Fragile Families and Child Wellbeing Study, we show that those who grow up in highly disadvantaged environments have shorter telomeres than boys who grow up in highly advantaged environments. We also find that the association between the social environment and TL is moderated by genetic variation within the serotonin and dopamine pathways. Boys with the highest genetic sensitivity scores had the shortest TL when exposed to disadvantaged environments and the longest TL when exposed to advantaged environments. To our knowledge, this report is the first to document a gene–social environment interaction for TL, a biomarker of stress exposure.

DOI:10.1073/pnas.1404293111 (Full Text)

PMCID: PMC4000782. (Pub Med Central)

AltMetrics Info

Country of focus: United States of America.

Browse | Search : All Pubs | Next