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Academic innovation & the global public research university, James Hilton
Reed, B.D., Sioban D. Harlow, L.J. Legocki, M.E. Helmuth, H.K. Haefner, B.W. Gillespie, and A. Sen. 2013. "Oral contraceptive use and risk of vulvodynia: a population-based longitudinal study." BJOG: An International Journal of Obstetrics and Gynaecology, 120(13): 1678-1684.
Objective To assess whether the risk of vulvodynia is associated with previous use of oral contraceptives (OCs). Design Longitudinal population-based study. Setting Four counties in south-east Michigan, USA. Population A population-based sample of women, aged 18 years and older, enrolled using random-digit dialling. Methods Enrolled women completed surveys that included information on demographic characteristics, health status, current symptoms, past and present OC use, and a validated screen for vulvodynia. The temporal relationship between OC use and subsequent symptoms of vulvodynia was assessed using Cox regression, with OC exposure modelled as a time-varying covariate. Main outcome measure Vulvodynia, as determined by validated screen. Results Women aged <50 years who provided data on OC use, completed all questions required for the vulvodynia screen, and had first sexual intercourse prior to the onset of vulvodynia symptoms were eligible (n = 906). Of these, 71.2% (n = 645) had used OCs. The vulvodynia screen was positive in 8.2% (n = 74) for current vulvodynia and in 20.8% (n = 188) for past vulvodynia. Although crude cross-tabulation suggested that women with current or past vulvodynia were less likely to have been exposed to OCs prior to the onset of pain (60.7%), compared with those without this disorder (69.3%), the Cox regression analysis identified no association between vulvodynia and previous OC use (HR 1.08, 95% CI 0.81-1.43, P = 0.60). This null finding persisted after controlling for ethnicity, marital status, educational level, duration of use, and age at first OC use. Conclusion For women aged <50 years of age, OC use did not increase the risk of subsequent vulvodynia. © 2013 RCOG.
PMCID: PMC3970290. (Pub Med Central)