Monday, Dec 9
Sharon Kardia: Genomics in the Health & Retirement Study
a PSC Research Project
This project will capitalize on, extend, and enhance the Chicago Community Adult Health Study (CCAHS), (P50 HD 38986) which is designed to become a major prospective multi-level study of the impact of individual and social environmental factors on health, their role in understanding socioeconomic and racial-ethnic disparities in health, and the biological and behavioral pathways that are involved. This project has completed a major survey of a probability sample of 3105 adults age 18+ in the city of Chicago, with a response rate of 71.8% and including physical measurements of height, weight, waist, hip length, and blood pressure. In addition, saliva and a blood sample have been collected for 681 people (about 60% of respondents a subsample of 80 of the 342 neighborhood clusters (NCs) covering the entire city of Chicago, developed and characterized by the Project on Human Development in Chicago Neighborhoods (PHDCN) (http://phdcn.harvard.edu/), from which the CCAHS sample is drawn. In addition to utilizing existing and collecting new archival data on these areas, the CCAHS carried out Systematic Social Observations of all 1672 blocks containing sampled households for the study. Thus, the current proposal seeks to utilize all these data to extend and enhance the CCAHS as follows: 1) to estimate via state of the art multi-level analysis the role in health and health disparities of the immediate social contexts or “neighborhoods” in which people live, 2) to estimate via innovative new methods the role in health and health disparities of the broader social contexts which surround more immediate residential contexts, 3) to estimate how a wide range of aspects of immediate residential contexts and broader social contexts (assessed by multiple methods and measures and considered both singly and in interaction with each other and individual and household factors) affect health and health disparities and help to understand or flesh out the role of social context in health, and 4) to begin to convert the existing cross-sectional study into a longitudinal and prospective study via mortality follow-up and respondent tracking, which will allow initial prospective analyses of the predictive association with health of unusually comprehensive set of individual, household, and contextual psychosocial risk factors for health assessed in the CCAHS, and prepare for a second wave of data collection in 2007-9, which will be funded by a subsequent competing renewal proposal.
|Funding:||Eunice Kennedy Shriver National Institute of Child Health and Human Development (1 R01 HD050467)|
Funding Period: 05/01/2006 to 02/28/2011
Project website: http://isr.umich.edu/ccahs/
Country of Focus: USA