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SWAN IV Pulse Wave Velocity - Subcontract

a PSC Research Project

Investigators:   Sioban D. Harlow, Elizabeth Jackson

This Competitive Revision to U01-AG-12553 proposes to add measures of aortic pulse wave velocity (aPWV), a measure of vascular aging to six clinical centers participating in the Study of Women?s Health Across the Nation (SWAN). SWAN is a multi-center, multi-ethnic longitudinal study designed to characterize the physiological and psychosocial changes that occur during the menopausal transition and to observe their effects on subsequent health and risk factors for age-related diseases. The cohort includes 3,302 women from five racial ethnic groups including Caucasian, African American, Hispanic, Chinese, and Japanese. Going into the year 12 follow-up, the women are now an average age of 58 years and 90% have achieved their final menstrual period. Thus, the women are positioned at early post-menopause, the time when cardiovascular events begin a rapid rise. Aortic PWV, a functional measure of early vascular aging, will be complimentary to the structural information already being collected in the form of common carotid intima-media thickness (IMT) and adventitial diameter (AD). Vascular aging is expected to be related to each of the key focus areas of SWAN including physical function, cognitive function, psychosocial measures and bone metabolism as well as future CV events. The addition of aPWV will allow us to evaluate 1) ethnic differences in early vascular aging and the degree to which risk factors influencing vascular aging differ by ethnicity; 2) the extent to which early vascular aging is influenced by reproductive hormones; 3) the extent to which early vascular aging is associated with other processes of aging including physical function, cognitive function, emotional health and bone metabolism; and 4) the association between structural measures of early vascular disease and functional measures of early vascular aging. This information is important because it will allow us to understand globally how vascular aging ties in with age-related disease and disability. The early postmenopausal years coincide with the time period preceding major disabilities. Understanding vascular aging during this period will allow us to learn more about the evolution of disease and disability in women. Because vascular aging underlies many conditions of aging, this study will allow us to identify potential points of intervention that may delay or prevent disease and disability in women.

Funding Period: 08/01/2011 to 04/30/2013

Country of Focus: USA

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