Monday, Dec 9
Sharon Kardia: Genomics in the Health & Retirement Study
a PSC Research Project
Investigators: Charles Burant, Karen Eileen Peterson, Martin Myers, Subramaniam Pennathur, Kenneth Resnicow, James D. Cavalcoli, Robert T. Kennedy, Jon K. Zubieta, Jeffrey F. Horowitz, Catherine A. Spino, Paul Mark Gordon, Caroline R. Richardson, Amy Elizabeth Rothberg, Nathan R. Qi, Charles Robert Evans, Jaeman Byun, Arun Kumar Das, Sioban D. Harlow, Alla Karnovsky, Stephen Brown, Malcolm J. Low, Ormond A. MacDougald
The Michigan Nutrition Obesity Research Center (MNORC) is an entity created to support, integrate and enhance research related to obesity and nutrition among the faculty at the University of Michigan. The focus of the MNORC is on obesity and obesity related-diseases. The goal of the MNORC is to create an infrastructure to encourage and enable researchers from preclinical, clinical and translational research disciplines to integrate advanced, phenotyping and computational tools to more fully define individual and population characteristics that arise in response to dietary nutrient composition or amount. The tools will include, but be not limited to those supporting molecular, metabolic and neurobehavioral phenotyping and will be accessible to preclinical, clinical and population-based researchers. This goal will be met by the support of integrated Core Laboratories and a Demonstration Unit (the Investigational Weight Management Clinic), support and development of symposia, seminars, courses and clinical immersion opportunities. Core laboratories will include the Administrative Core, which will oversee and integrate the research, clinical and education functions of the Center; the Human Phenotyping Core, which will provide expertise and infrastructure for sophisticated metabolic and neurobehavioral testing of humans in inpatient and outpatient settings including advanced imaging technologies; the Molecular Phenotyping Core, composed of 3 laboratories for lipomics, directed metabolomics and untargeted metabolomics and equipment for in vitro measurement of cellular metabolism; the Animal Phenotyping Core which will provide similar services for the molecular, metabolic and neurobehavioral phenotyping of rodent models of altered nutrition and obesity; and the Integrated Biostatistics and Informatics Core, which will provide personnel to assist investigators in design of experiments integrating different levels of phenotyping in addition to data management and advanced bioinformatics tools for integration, interpretation, visualization and reporting of molecular, metabolic and neurobehavioral data. The MNORC will support a large research base and will work to increase the number, productivity and collaborations among of researchers focusing on nutrition interventions and obesity and obesity-related conditions. The Center will also provide educational and career development opportunities for students, fellows and junior faculty. Through these efforts, the MNORC will provide knowledge, techniques and tools that will improve the health of the individual and of the community.
|Funding:||National Institute of Diabetes and Digestive and Kidney Diseases (5P30DK089503)|
Funding Period: 07/01/2010 to 06/30/2015