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Michigan Lupus Epidemiology & Surveillance (MILES) Program Longitudinal Cohort

a PSC Research Project

Investigators:   Emily Catherine Somers, William J. McCune, Wendy E. Marder, Lu Wang, Afton Hassett, Sioban D. Harlow, Suzie M. Zick

This proposal is to extend the Michigan Lupus Epidemiology & Surveillance (MILES) Program beyond the nearly completed public health surveillance phase to a research phase, by creating and maintaining a longitudinal cohort and biorepository, which will include both lupus cases from the registry and population-based controls. Data collection for all participants will include a number of measures related to health/wellness, physical function, pain and for female participants a number of items related to womens health. Lupus-specific measures, including disease activity indices, will be assessed for the SLE patients. The biorepository will include serum, plasma, PBMCs, DNA isolated both from unfractionated PBMCs and CDC4+ subsets, hair and nails. Vaginal swabs for female participants of reproductive age will be collected, allowing for HPV DNA assays. Specimens will be stored in appropriate conditions to allow for genotyping and future investigation of biomarkers of both disease and exposure. An emphasis will be placed on providing the capability to perform DNA methylation assays relevant to autoimmunity. Lastly, this proposal will support the performance of ImmunoChip genotyping for validation of high-risk SLE alleles in the African-American population.

Funding Period: 09/30/2012 to 09/29/2016

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