Lipid-Lowering Medication and Risk of Injury
Bovbjerg, Viktor E., David S. Siscovick, Bruce M. Psaty, Barbara S. McCann, Thomas D. Koepsell, Trivellore Raghunathan, and Edward H. Wagner. 1999. "Lipid-Lowering Medication and Risk of Injury." Journal of Clinical Epidemiology, 52(12): 1197-1200.
Meta-analyses of early primary prevention trials of lipid-lowering therapies suggested increased risk of injury deaths among treated persons. Our population-based case-control study examined the association of lipid-lowering medication use with fatal and nonfatal injuries in 298 cases and 332 controls. No increased injury risk was observed among current (OR = 0.46, 95% CI 0.18-1.21) or past users (OR = .92, 95% CI 0.44-1.95), after adjustment for behavioral disorders, medical conditions, and health status. Stratified analyses did not reveal sub-groups at significantly increased risk. These results, consistent with recent clinical trials and meta-analyses, suggest no increased injury risk associated with lipid-lowering medications.
Anticholesterolemic agents cholesterol lipoproteins injury coronary disease case-control study