Use of low-dose oral contraceptives and stroke in young women

Archived Abstract of Former PSC Researcher

Schwartz, Stephen M., David S. Siscovick, W.T. Longstreth Jr, Bruce M. Psaty, R. Kevin Beverly, Trivellore Raghunathan, Dan-Yu Lin, and Thomas D. Koepsell. 1997. "Use of low-dose oral contraceptives and stroke in young women." Annals of Internal Medicine, 127: p596(8).

Background: Low-dose oral contraceptives are widely used, but there are limited data on the cerebrovascular risks associated with these medications. Objective: To determine whether use of low-dose oral contraceptives influences the risk for stroke. Design: Population-based case-control study. Setting: Women 18 to 44 years of age who resided in western Washington State between 1991 and 1995. Participants: Patients with ischemic stroke (n = 60), hemorrhagic stroke (n = 102), and other types of stroke (n = 11) and controls identified through random-digit dialing (n = 485). Measurements: Details about oral contraceptive use and other risk factors for stroke were obtained through in-person interviews. Results: The estimated incidences of hemorrhagic stroke and ischemic stroke were 6.4 and 4.3 per 100 000 women-years, respectively. Compared with women who had never used oral contraceptives (after adjustment for risk factors for stroke), current users of low-dose oral contraceptives had estimated odds ratios of 0.93 (95% Cl, 0.37 to 2.31) for hemorrhagic stroke and 0.89 (Cl, 0.27 to 2.94) for ischemic stroke. Compared with past users of oral contraceptives, current users had odds ratios of 1.41 (Cl, 0.67 to 2.96) for hemorrhagic stroke and 1.37 (Cl, 0.49 to 3.81) for ischemic stroke. For past users compared with never users, the odds ratios were 0.59 (Cl, 0.30 to 1.18) for hemorrhagic stroke and 0.57 (Cl, 0.25 to 1.32) for ischemic stroke. The odds ratio for hemorrhagic stroke in current users of low-dose oral contraceptives containing norgestrel or levonorgestrel was elevated (3.23 [Cl,1.24 to 8.41]). Among patients with hemorrhagic stroke, the odds ratio for aneurysmal bleeding associated with current use of low-dose oral contraceptives containing norgestrel or levonorgestrel was 4.46 (Cl, 1.58 to 12.53). Conclusions: The overall risk for stroke and type of stroke was not increased among current users of low-dose oral contraceptives in the study population. Larger studies are needed to clarify both the relation of risk for stroke to past use of oral contraceptives and the possible association between current use of norgestrel-containing oral contraceptives and hemorrhagic stroke.; Women who take low-dose oral contraceptives do not appear to have a significantly increased risk of stroke. Oral contraceptive use was evaluated among 102 women with strokes related to blood clots, 60 women with strokes related to vessel narrowing, 11 women with other stroke types, and 485 healthy volunteers. Risk for any type of stroke was not significantly higher among women who had taken oral contraceptives compared to those never using this birth control method.

http://www.annals.org/content/127/8_Part_1/596.full.pdf+html

Keywords:
Complications and side effects Risk factors Health aspects Oral contraceptives_Adverse and side effects Stroke_Risk factors Women's health_Health aspects Stroke (Disease)_Risk factors Women_Health aspects

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