Analysis of Binary Data from a Multicentre Clinical Trial

Archived Abstract of Former PSC Researcher

Raghunathan, Trivellore, and Yoichi II. 1993. "Analysis of Binary Data from a Multicentre Clinical Trial." Biometrika, 80(1): 127-139.

We develop several methods for estimating the treatment effect difference defined as the overall log-odds ratio of favourable response in a multicentre clinical trial comparing two treatments with binary response. A simulation study compares the bias and mean squared error of the point estimates and the exact coverage probabilities of confidence intervals obtained distributions.

http://links.jstor.org/sici?sici=0006-3444%28199303%2980%3A1%3C127%3AAOBDFA%3E2.0.CO%3B2-7

Keywords:
Categorical data Conditional likelihood EM-algorithm Empirical Bayes Mixed model

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