Analysis of Binary Data from a Multicentre Clinical Trial
Raghunathan, Trivellore, and Yoichi II. 1993. "Analysis of Binary Data from a Multicentre Clinical Trial." Biometrika, 80(1): 127-139.
We develop several methods for estimating the treatment effect difference defined as the overall log-odds ratio of favourable response in a multicentre clinical trial comparing two treatments with binary response. A simulation study compares the bias and mean squared error of the point estimates and the exact coverage probabilities of confidence intervals obtained distributions.
Categorical data Conditional likelihood EM-algorithm Empirical Bayes Mixed model