Prospective associations between beverage intake during the midlife and subclinical carotid atherosclerosis: The Study of Women's Health Across the Nation

Archived Abstract of Former PSC Researcher

Wang, Dongqing, Carrie Anne Karvonen-Gutierrez, Elizabeth A. Jackson, Michael R. Elliott, Bradley M. Appelhans, Emma Barinas-Mitchell, Lawrence F. Bielak, and Ana Baylin. 2019. "Prospective associations between beverage intake during the midlife and subclinical carotid atherosclerosis: The Study of Women's Health Across the Nation." PLOS ONE, 14(7): e0219301.

Background:

The potential impacts of beverage intake during the midlife on future subclinical atherosclerosis among women are unclear. The aim of this study was to evaluate the prospective associations between the intakes of eight beverage groups and subclinical carotid atherosclerosis in midlife women.

Methods:

Data came from the Study of Women's Health Across the Nation, a multicenter, multiethnic, and prospective cohort study. A total of 1,235 midlife women had measures of subclinical carotid atherosclerosis and repeatedly beverage intake data collected using a validated food frequency questionnaire. Beverages were aggregated into eight groups, including coffee, tea, sugar-sweetened beverages, artificially sweetened beverages, fruit juices, whole milk, milk with lower fat content, and alcoholic beverages. The associations of beverage intake with common carotid artery intima-media thickness (CCA-IMT) and adventitial diameter (CCA-AD) were estimated using linear models; the associations with carotid plaque were estimated using log-binomial models.

Results:

Coffee intake was associated with CCA-IMT in an inverted J-shaped pattern. After adjusting for covariates, women with >0 to <1 cup/day and 1 to <2 cups/day of coffee intake had a 0.031 mm (95% CI: 0.012, 0.051) and a 0.027 mm (95% CI: 0.005, 0.049) larger CCA-IMT, respectively, than coffee non-drinkers. Women who consumed ≥2 cups/day of coffee did not have significantly different CCA-IMT than non-drinkers. There was an inverse linear association between moderate alcoholic beverages intake and CCA-IMT (P-trend = 0.014). Whole milk intake had inverted U-shaped associations with CCA-IMT and carotid plaque. No significant associations were found between other beverage groups and subclinical atherosclerosis.

Conclusions:

In midlife women, occasional coffee intake may be associated with more subclinical atherosclerosis while moderate alcoholic beverages intake may be associated with less subclinical atherosclerosis. Future work should focus on the determination of the optimal beverage intake profile for maximum cardiovascular benefits in midlife women.

10.1371/journal.pone.0219301

Keywords:
Population Health Methodology

Browse | Search | Next

PSC In The News

RSS Feed icon

Miller comments on local efforts to provide healthcare to vulnerable populations

Shaefer discusses Americans with tight financial resources have fewer options as they navigate coronavirus closures and layoffs in NYT

Mehta's research on life expectancy crisis in the USA: The opioid crisis is not the decisive factor

More News

Highlights

Data Scientist Job Open at PSC/PDHP

New Investigator Mentoring Program (PDHP) Applications Sought

More Highlights


Connect with PSC follow PSC on Twitter Like PSC on Facebook