Modeling cortisol rhythms in a population-based study
Ranjit, N., E.A. Young, Trivellore Raghunathan, and George A. Kaplan. 2005. "Modeling cortisol rhythms in a population-based study." Psychoneuroendocrinology, 30(7): 615-624.
The aim of these analyses was to develop and describe easily implementable, yet information rich, approaches for analysis of the temporal profile of cortisol in human populations. A typical waking profile of cortisol in a sample of women aged 15-44 was parameterized by a piecewise Linear regression model, implemented as a mixed model to accommodate repeated observations among individuals. The model was extended to distinguish characteristic cortisol profiles of obese women from those of non-obese women. Sharp inflection points for the diurnal profile of cortisol were noted at 30 and 75 min past awakening. Obese women showed a slight tendency to have a less sharply rising and declining response to awakening than non-obese women.
Country of focus: United States of America.