The ReSTAGE Collaboration: defining optimal bleeding criteria for onset of early menopausal transition

Archived Abstract of Former PSC Researcher

Harlow, Sioban D., E.S. Mitchell, S. Crawford, B. Nan, R. Little, and J. Taffe. 2008. "The ReSTAGE Collaboration: defining optimal bleeding criteria for onset of early menopausal transition." Fertility and Sterility, 89(1): 129-140.

Objective Criteria for staging the menopausal transition are not established. This article evaluates five bleeding criteria for defining early transition and provides empirically based guidance regarding optimal criteria.

Design/Setting Prospective menstrual calendar data from four population-based cohorts: TREMIN, Melbourne Women's Midlife Health Project (MWMHP), Seattle Midlife Women's Health Study (SMWHS), and Study of Women's Health Across the Nation (SWAN) with annual serum FSH from MWMHP and SWAN.

Participants 735 TREMIN, 279 SMWHS, 216 MWMHP, and 2270 SWAN women aged 35–57 at baseline who maintained menstrual calendars.

Main Outcome Measure(s) Age at and time to menopause for: standard deviation >6 and >8 days, persistent difference in consecutive segments >6 days, irregularity, and ≥45 day segment. Serum FSH concentration.

Result(s) Most women experienced each of the bleeding criteria. Except for a persistent >6 day difference that occurs earlier, the criteria occur at a similar age and at approximately the same age as late transition in a large proportion of women. FSH was associated with all proposed markers.

Conclusion(s) The early transition may be best described by ovarian activity consistent with the persistent >6 day difference, but further study is needed, as other proposed criterion are consistent with later menstrual changes.

10.1016/j.fertnstert.2007.02.015

PMCID: PMC2225986. (Pub Med Central)

Country of focus: United States of America.

Browse | Search | Books | Next

PSC In The News

RSS Feed icon

Shaefer comments on the Cares Act impact in negating hardship during COVID-19 pandemic

Heller comments on lasting safety benefit of youth employment programs

More News

Highlights

Dean Yang's Combatting COVID-19 in Mozambique study releases Round 1 summary report

Help Establish Standard Data Collection Protocols for COVID-19 Research

More Highlights


Connect with PSC follow PSC on Twitter Like PSC on Facebook