Home > Publications . Search All . Browse All . Country . Browse PSC Pubs . PSC Report Series

PSC In The News

RSS Feed icon

Stephenson et al find "alarmingly high rates" of intimate partner violence among male couples

Stafford's findings on gender gap in children's allowances suggest entrenched nature of wage gap

Sastry et al. find parents with childhood trauma more likely to have children with behavioral health problems

More News

Highlights

Social Science One making available data that "may rival the total amount that currently exists in the social sciences"

West et al. examine HS seniors' nonmedical use of prescription stimulants to boost study

Bobbi Low retires

Seefeldt promoted to associate professor of social work, associate professor of public policy

More Highlights

Next Brown Bag

More PSC brown bags, Fall 2018

Estimation of Background Serum 2,3,7,8-TCDD Concentrations By Using Quantile Regression in the UMDES and NHANES Populations

Publication Abstract

Garabrant, D.H., Michael R. Elliott, James M. Lepkowski, Q.X. Chen, E. Hedgeman, R.J. Little, B. Gillespie, B. Hong, et al. 2010. "Estimation of Background Serum 2,3,7,8-TCDD Concentrations By Using Quantile Regression in the UMDES and NHANES Populations." Epidemiology, 21: S51-S57.

Background: The goal of the present study was to quantify the population-based background serum concentrations of 2,3,7,8-tetra-chlorodibenzo-p-dioxin (TCDD) by using data from the reference population of the 2005 University of Michigan Dioxin Exposure Study (UMDES) and the 2003-2004 National Health and Nutrition Examination Survey (NHANES). Methods: Multiple imputation was used to impute the serum TCDD concentrations below the limit of detection by combining the 2 data sources. The background mean, quartiles, and 95th percentile serum TCDD concentrations were estimated by age and sex by using linear and quantile regressions for complex survey data. Results: Any age- and sex-specific mean, quartiles, and 95th percentiles of background serum TCDD concentrations of study participants between ages 18 and 85 years can be estimated from the regressions for the UMDES reference population and the NHANES non-Hispanic white population. For example, for a 50-year-old man in the reference population of UMDES, the mean, quartiles, and 95th percentile serum TCDD concentrations are estimated to be 1.1, 0.6, 1.1, 1.8, and 3.3 parts per trillion, respectively. The study also shows that the UMDES reference population is a valid reference population for serum TCDD concentrations for other predominantly white populations in Michigan. Conclusion: The serum TCDD concentrations increased with age and increased more over age in women than in men, and hence estimation of background concentrations must be adjusted for age and sex. The methods and results discussed in this article have wide application in studies of the concentrations of chemicals in human serum and in environmental samples.

DOI:10.1097/EDE.0b013e3181ce9550 (Full Text)

Country of focus: United States of America.

Browse | Search : All Pubs | Next