Home > Publications . Search All . Browse All . Country . Browse PSC Pubs . PSC Report Series

PSC In The News

RSS Feed icon

Miller et al. find benefits of Medicaid for pregnant mothers in 1980s carry over two generations

Starr's findings account for some of the 19% black-white gap in federal sentencing

Frey says suburbs are aging, cities draw millennials

More News

Highlights

Bailey et al. find higher incomes among children whose parents had access to federal family planning programs in the 1960s and 70s

U-M's campus climate survey results discussed in CHE story

U-M honors James Jackson's groundbreaking work on how race impacts the health of black Americans

U-M is the only public and non-coastal university on Forbes' top-10 list for billionaire production

More Highlights

Next Brown Bag

Mon, Jan 22, 2018, noon: Narayan Sastry

The impact of continuous subcutaneous insulin infusion and multiple daily injections of insulin on glucose variability in older adults with type 2 diabetes

Archived Abstract of Former PSC Researcher

Johnson, Susan L., L. McEwen, C. Newton, C. Martin, P. Raskin, Jeffrey Halter, and W. Herman. 2011. "The impact of continuous subcutaneous insulin infusion and multiple daily injections of insulin on glucose variability in older adults with type 2 diabetes." Journal of Diabetes and Its Complications, 25(4): 211-215.

Aims: To determine whether continuous subcutaneous insulin infusion (CSII) or multiple daily injections of insulin (MDI) are associated with improved glycemic variability. Methods: Type 2 diabetic patients >= 60 years of age were randomized to 12 months of CSII (n=53) or MDI (n=54) therapy. Patients were asked to complete monthly eight-point self-monitored glucose profiles (n=78) and continuous glucose monitoring systems (CGMS) for up to 72 h at Months 0, 6, and 12 (n=77). Within-day mean glucose, standard deviation (SD), range, pre- and post-prandial glucose, M value, and mean amplitude of glycemic excursions (MACE) were calculated from eight-point profiles. Mean glucose, SD, range, area under the curve (AUC) high (>180 mg/dl) and AUC-low (<70 mg/dl) were calculated from CGMS. Mixed model analyses of variance were used to examine the associations between treatment, time, and the study outcomes, adjusting for any effects of sex. Results: With the use of the eight-point profiles, CSII and MDI groups did not differ with respect to mean glucose, mean pre-prandial and post-prandial glucose, SD, range, M value, or MACE. With the CGMS data, there were no significant between-group differences in measures of mean glucose, range, SD, AUC-high, or AUC-low. In both treatment groups, all measures improved over time (P<.0001) except for AUC-low (P=.68) which did not change. There were treatment-by-time interactions when considering the CGMS range (P=.04) and AUC-high (P=.001), but no significant differences were found at individual time points. Conclusions: Glucose variability improved equally with CSII and MDI treatment in older patients with type 2 diabetes. (C) 2011 Elsevier Inc. All rights reserved.

DOI:10.1016/j.jdiacomp.2010.09.005 (Full Text)

Browse | Search : All Pubs | Next