Home > Publications . Search All . Browse All . Country . Browse PSC Pubs . PSC Report Series

PSC In The News

RSS Feed icon

Work by Geronimus cited in account of Serena Williams' maternal health complications

Alexander and Massey compare outcomes for children whose parents did and did not take part in Great Migration

Geronimus on pushing past early dismissal of her weathering hypothesis

More News

Highlights

Robert Wood Johnson Foundation health leadership development programs accepting applications

AA named 2018 Best Place to Live in America (out of 100 cities)

Remembering Jim Morgan, founding member of ISR and creator of the PSID

1/17/18: ISR screening and discussion of documentary "Class Divide" at Michigan Theater

More Highlights

Next Brown Bag

Mon, Jan 22, 2018, noon: Narayan Sastry

David Weir photo

Genome-wide Association Analysis of Blood-Pressure Traits in African-Ancestry Individuals Reveals Common Associated Genes in African and Non-African Populations

Publication Abstract

Weir, David, Sharon L. R. Kardia, Jennifer A. Smith, and Jessica Faul, et al. 2013. "Genome-wide Association Analysis of Blood-Pressure Traits in African-Ancestry Individuals Reveals Common Associated Genes in African and Non-African Populations." American Journal of Human Genetics, 93(3): 545-554.

High blood pressure (BP) is more prevalent and contributes to more severe manifestations of cardiovascular disease (CVD) in African Americans than in any other United States ethnic group. Several small African-ancestry (AA) BP genome-wide association studies (GWASs) have been published, but their findings have failed to replicate to date. We report on a large AA BP GWAS meta-analysis that includes 29,378 individuals from 19 discovery cohorts and subsequent replication in additional samples of AA (n = 10,386), European ancestry (EA) (n = 69,395), and East Asian ancestry (n = 19,601). Five loci (EVX1-HOXA, ULK4, RSPO3, PLEKHG1, and SOX6) reached genome-wide significance (p < 1.0 x 10(-8)) for either systolic or diastolic BP in a transethnic meta-analysis after correction for multiple testing. Three of these BP loci (EVX1-HOXA, RSPO3, and PLEKHG1) lack previous associations with BP. We also identified one independent signal in a known BP locus (SOX6) and provide evidence for fine mapping in four additional validated BP loci. We also demonstrate that validated EA BP GWAS loci, considered jointly, show significant effects in AA samples. Consequently, these findings suggest that BP loci might have universal effects across studied populations, demonstrating that multiethnic samples are an essential component in identifying, fine mapping, and understanding their trait variability.

DOI:10.1016/j.ajhg.2013.07.010 (Full Text)

PMCID: PMC3769920. (Pub Med Central)

Browse | Search : All Pubs | Next