Home > Research . Search . Country . Browse . Small Grants

PSC In The News

RSS Feed icon

Miller et al. find benefits of Medicaid for pregnant mothers in 1980s carry over two generations

Starr's findings account for some of the 19% black-white gap in federal sentencing

Frey says suburbs are aging, cities draw millennials

More News

Highlights

Bailey et al. find higher income among children whose parents had access to federal family planning programs in the 1960s and 70s

U-M's campus climate survey results discussed in CHE story

U-M honors James Jackson's groundbreaking work on how race impacts the health of black Americans

U-M is the only public and non-coastal university on Forbes' top-10 list for billionaire production

More Highlights

Next Brown Bag

Mon, Jan 22, 2018, noon: Narayan Sastry

Arline T. Geronimus photo

Race/Ethnicity, Psychosocial and Environmental Stressors, and Telomere Length

a PSC Research Project [ARCHIVE DISPLAY]

Investigators:   Arline T. Geronimus, Amy Jo Schultz

We are conducting the first community-based study of racial differences in telomere length and allostatic load in adults of broad age range and their association with urban stressors. We hypothesize that chronic stressors experienced by black urban residents accelerate biological aging and chronic disease onset.

Evidence suggests that leukocyte telomere length (TL) may be an indicator of biological age that can be affected by stress; and that allostatic load is an indicator of stress-mediated wear on important body systems. We have a unique opportunity to supplement survey data scheduled to be collected by the Healthy Environments Partnership (HEP) – a partnership between the University of Michigan and community-based organizations and health service agencies in Detroit – with blood collection and lab analyses of TL, telomere-related compounds, and allostatic load, including measures of the biological stress response, inflammation, and cardiovascular and metabolic risk. By appending a venous blood draw to the HEP survey, we can construct a data set including these biomeasures and detailed psychosocial and physical environmental measures in a cost-effective way; enhance access to a hard-to-reach population; and facilitate dissemination of study results to improve community health.

We will estimate a series of regressions of TL and allostatic load on race, controlling for the confounding effects of age, gender, and socioeconomic characteristics and exploring the extent to which psychosocial or environmental stressors mediate remaining racial differences. To ensure findings are not driven by functional form we will reanalyze the data using matching methods. We will also model disease outcomes, conditional on telomere length, on high oxidative stress or low telomerase activity to explore biological mechanistic pathways between telomere length and chronic disease.

We expect study findings to shed light on the plausibility of cumulative stress hypotheses to explain the social patterning of disease; the viability of telomere length as a biomeasure of aging; and the mechanistic pathways through which stressors may be linked to telomere length and disease processes. If findings from this interdisciplinary collaborative effort support study hypotheses, this could constitute a significant advance in the understanding of the biological mechanisms that underlie racial inequality in health.

Funding Period: 09/01/2008 to 06/30/2014

Country of Focus: USA

This PSC Archive record is displayed for historical reference.

Search . Browse