Validation and Extension of the Michigan Barrett's Esophagus pREdiction Tool (M-Beret)
1) To compare the discrimination by the M-BERET to a conventional model utilizing only GERD symptoms for predicting the presence of BE and early neoplastic BE.
2) To compare the discrimination of BE by the M-BERET with and without the inclusion of information regarding circulating levels of leptin and IL-6, -8, -10, and -12p70.
3) To estimate the effects of psychological distress on the frequency of BE among patients with GERD symptoms inadequately responding to PPI.
4) To compare the discrimination of the M-BERET to a conventional model utilizing only GERD symptoms for predicting the incidence of esophageal adenocarcinoma in a retrospective longitudinal cohort.
Veterans Affairs, Department of
Funding Period: 5/9/2016 to 5/8/2019