Identifying modifiable aspects of gene-by-environment interplay in later-life cognitive decline
With data from four large national studies in the US and UK, this project will test the hypothesis that protective socioeconomic, work, and policy environments moderate the genetic risk for dementia and cognitive decline. Using results from existing genome-wide association studies (GWAS), researchers will create measures of genetic risk; evaluate how gene-by-environment (GxE) interplay evolves over the lifecycle; identify modifiable characteristics of the environment; establish the direction of causality; and, when possible, investigate mechanisms that give rise to GxE interplay.
In this subcontract, Michigan researchers will (1) help navigate the administrative hurdles to downloading survey and genetic data through the official channels, 2) conceptualize research questions related to cognition and genetics, 3) oversee genotype data management and preparation, including creating and interpreting genetic risk and burden scores used for analyses, 4) conduct analyses, and 5) prepare a study paper.
Funding: National Institute on Aging (subcontract: 1 RF1 AG 055654 01 A1)
Funding Period: 9/15/2017 to 6/30/2022