David Weir

Health and Retirement Study (HRS) Neuroimaging Pilot Study

Research Project Description
Kenneth M. Langa, David Weir, Lindsay Ryan, Robert A. Koeppe, Benjamin Hampstead, Judith L. Heidebrink

Cognitive impairment, Alzheimer's disease, and Alzheimer's disease-related dementias (AD/ADRD) are common and costly among older adults in the United States, leading to decreased quality of life, disability in daily activities, a large burden of unpaid family caregiving, and significant long term care costs borne both by families and public programs. To provide the research community with new and richer data to study the prevalence, predictors, and outcomes of cognitive decline, the Health and Retirement Study (HRS) undertook the Harmonized Cognitive Assessment Protocol (HCAP) Study during the HRS 2016 field period, in which we administered a supplemental in-home 1-hour battery of cognitive tests to about 3200 randomly selected and nationally representative HRS respondents aged 65+, as well as a 20-minute informant interview. Since there is increasing interest in the potential utility of biomarker and imaging data to better diagnose and risk-stratify older adults with pre-clinical and very early AD, performing neuroimaging in the HCAP sample, as conducted by the Alzheimer's Disease Neuroimaging Initiative (ADNI), would greatly enhance the value of the HCAP and would support new opportunities for inter-disciplinary research on AD in a nationally representative sample of US adults. However, the feasibility of conducting neuroimaging in broad-based population-representative studies not originally recruited for that purpose has not been demonstrated. We therefore propose to conduct a pilot study of neuroimaging in 100 HRS-HCAP subjects at three ADNI sites (Columbia University, University of Michigan, and University of Southern California) in order to develop best practices, and determine the cost and feasibility of neuroimaging within the HRS.

Alzheimer's Association
(Award Agreement)

Funding Period: 3/1/2018 to 2/28/2020

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