Biological and social mediators of child wellbeing among ethnic groups in Fragile Families
Continuing the tradition of service that has marked Fragile Families and Child Wellbeing Study (FFCW) from the beginning, in the first year of this renewal project we plan to develop a portfolio of relatively new measures based on data acquired during the current funding period (multiple polygenetic scores, including several that exploit gene expression or experimental data to enhance the predictive power for particular phenotypes, (CNV annotated to gene, meQTL and EWAS). All of these derived measures would, initially, involve analysis of existing data, and would be completed and made publicly available by year 1 of the award. Due to the composition of our population, these statistics would provide important new tools for the genetic assessment of ethnic minority populations. We also plan to develop and release a set of user-friendly computational tools for quality testing and analysis of DNA methylation, genotype, CNVs, and telomere length. This work takes on greater value due to recent calls to expand genome-wide work for non-European Ancestry (in particular African and Hispanic) individuals and in children.
Eunice Kennedy Shriver National Institute of Child Health and Human Development
Funding Period: 5/1/2019 to 4/30/2024